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Gene and DNA Sequence
Record information and status
Record ID
102896
Status
Published
Date of creation
2011-12-07 16:16 UTC (german_bch@bvl.bund.de)
Date of last update
2012-07-09 13:47 UTC (dina.abdelhakim@cbd.int)
Date of publication
2012-07-09 13:47 UTC (dina.abdelhakim@cbd.int)

This document is also available in the following languages:
General information
Name of the gene or DNA sequence
Cholera Toxin
Abbreviation
CS-CTX
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
No
Donor organism
Donor organism
Vibrio cholerae
Characteristics of the protein coding sequence
Name of the protein expressed by the coding sequence
Cholera toxin
Biological function
An exotoxin, produced by Vibrio cholerae and Vibrio eltor, thats leeds to the massive, watery diarrhea characteristic of cholera infection.

The cholera toxin is a member of the AB family of toxins. The function of the non-toxic B subunit is to assemble into a ring-shaped, homologous pentamer and to adhere to mem-brane receptors on the intestinal epithelial cell surface (GM1 gangliosides). The pathogenic effect stems from the A subunit. This is split into two domains, an anchor domain A2 and a toxic domain A1. The anchor domain binds the toxic A1 domain to the B subunit. Through a series of further intermediate activation steps, the A1 domain ultimately causes a massive secretion of chloride ions in the gut lumen, causing diarrhoea. It follows that the A1 subunit is toxic, but the B subunit is non-toxic.
Related trait(s) or use(s) in biotechnology

Records referencing this document (3)
IDDescription
3record(s) found
Country's Decision or any other Communication1 record
Modified Organism1 record
Risk Assessment1 record