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Gene and DNA Sequence
Record information and status
Record ID
103024
Status
Published
Date of creation
2012-01-25 09:37 UTC (german_bch@bvl.bund.de)
Date of last update
2012-08-16 19:19 UTC (dina.abdelhakim@cbd.int)
Date of publication
2012-08-16 19:19 UTC (dina.abdelhakim@cbd.int)

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General information
Name of the gene or DNA sequence
Single-chain Fragment variable (scFv) antibody BA11
Abbreviation
CS-scFv BA11
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
Yes
Donor organism
Donor organism
Mus musculus - Mouse, House mouse, MOUSE
Characteristics of the protein coding sequence
Name of the protein expressed by the coding sequence
scFv BA11
Biological function
The single chain antibody scFv BA11 is a synthetic molecule comprised from the variable fragments of a complete IgG antibody which are linked by a synthetic peptide through phage display-technology. The scFv BA11 antibody targets F4-fimbria of enterotoxigenic Escherichia coli (ETEC) cells that attach to the intestinal wall of pigs and might cause diarrhea.
Related trait(s) or use(s) in biotechnology
Additional Information
Additional Information
Since single-chain antibodies are of small molecular size, they are especially suited for heterologous expression in bacteria, yeast and also plants. The scFv BA11 is such an antibody. In vitro studies demonstrated that scFv BA11 prevents the adhesion of F4-armed ETEC to the intestinal wall of pigs and, therefore, might prevent from the development of the "postweaning diarrhea (PWD)" of piglets. Heterologously expressed scFv BA11 might find diagnostic and therapeutic application.

Records referencing this document (3)
IDDescription
3record(s) found
Country's Decision or any other Communication1 record
Modified Organism1 record
Risk Assessment1 record