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Gene and DNA Sequence
Record information and status
Record ID
103069
Status
Published
Date of creation
2012-02-06 21:06 UTC (manoela.miranda@cbd.int)
Date of last update
2012-08-03 15:05 UTC (dina.abdelhakim@cbd.int)
Date of publication
2012-08-03 15:05 UTC (dina.abdelhakim@cbd.int)

General information
Name of the gene or DNA sequence
loxP recombination site
Abbreviation
V-loxP
Category of DNA sequence
  • recombination site
Is the gene / DNA sequence is a synthetic molecule?
No
Donor organism
Donor organism
Bacteriophage P1 - Phage P1
Additional Information
Additional Information
Lox P (locus of X-over P1) is a site on the Bacteriophage P1 consisting of 34 bp which is recognised by the site specific Cre recombinase.

When cells that have loxP sites in their genome express Cre, a recombination event can occur between the loxP sites. The double stranded DNA is cut at both loxP sites by the Cre protein. The strands are then rejoined with DNA ligase in a quick and efficient process. The result of recombination depends on the orientation of the loxP sites. For two lox sites on the same chromosome arm, inverted loxP sites will cause an inversion of the intervening DNA, while a direct repeat of loxP sites will cause a deletion event. If loxP sites are on different chromosomes it is possible for translocation events to be catalysed by Cre induced recombination.

Records referencing this document (48)
IDDescription
48record(s) found
Country's Decision or any other Communication21 records
Modified Organism5 records
Risk Assessment22 records