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Biosafety Virtual Library Resources
(VLR)
last updated: 10 May 2012
Problem Formulation and Hypothesis Testing for Environmental Risk Assessments of Genetically Modified Crops.
EN
EDP Sciences
EN
2006
EN
Environmental Biosafety Research
EN
© ISBR, EDP Sciences, 2007
EN
Abstract:
Environmental risk assessments can provide high confidence of minimal risk by testing theories, “risk hypotheses”, that predict the likelihood of unacceptable harmful events. The creation of risk hypotheses and a plan to test them is called problem formulation. Effective problem formulation seeks to maximize the possibility of detecting effects that indicate potential risk; if such effects are not detected, minimal risk is indicated with high confidence. Two important implications are that artificial test conditions can increase confidence, whereas prescriptive data requirements can reduce confidence (increase uncertainty) if they constrain problem formulation. Poor problem formulation can increase environmental risk because it leads to the collection of superfluous data that may delay or prevent the introduction of environmentally beneficial products.
EN
Environmental risk assessments can provide high confidence of minimal risk by testing theories, “risk hypotheses”, that predict the likelihood of unacceptable harmful events. The creation of risk hypotheses and a plan to test them is called problem formulation. Effective problem formulation seeks to maximize the possibility of detecting effects that indicate potential risk; if such effects are not detected, minimal risk is indicated with high confidence. Two important implications are that artificial test conditions can increase confidence, whereas prescriptive data requirements can reduce confidence (increase uncertainty) if they constrain problem formulation. Poor problem formulation can increase environmental risk because it leads to the collection of superfluous data that may delay or prevent the introduction of environmentally beneficial products.
No
No
No
Identifier (ISBN, ISSN, etc.)
DOI: 10.1051/ebr:2007004
Format
7 page PDF
Keywords and any other relevant information
Keywords: risk assessment / problem formulation / scientific method / certainty / data requirements
Citation: Environ. Biosafety Res. 5 (2006) 119–125