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Information Resource
Record information and status
Record ID
103467
Status
Published
Date of creation
2012-05-11 16:55 UTC (dina.abdelhakim@cbd.int)
Date of publication
2012-05-11 16:55 UTC (dina.abdelhakim@cbd.int)

General Information
Title
Insect population control using a dominant, repressible, lethal genetic system
Author
Dean D. Thomas, Christl A. Donnelly, Roger J. Wood, Luke S. Alphey
Author’s contact information
Luke S. Alphey
E-mail: Luke.Alphey@zoo.ox.ac.uk
Language(s)
  • English
Publication date
2000-03-31
Subject
Summary, abstract or table of contents
ABSTRACT:

A major modification to the sterile insect technique is described, in which transgenic insects homozygous for a dominant, repressible, female-specific lethal gene system are used. We demonstrate two methods that give the required genetic characteristics in an otherwise wild-type genetic background. The first system uses a sex-specific promoter or enhancer to drive the expression of a repressible transcription factor, which in turn controls the expression of a toxic gene product. The second system uses non-sex-specific expression of the repressible transcription factor to regulate a selectively lethal gene product. Both methods work efficiently inDrosophila melanogaster, and we expect these principles to be widely applicable to more economically important organisms.
Thematic areas
  • Scientific and technical issues
    • Risk assessment
Background material to the “Guidance on risk assessment of living modified organisms”
Is this document is recommend as background material for the “Guidance on Risk Assessment of Living Modified Organisms”
Yes
Section(s) of the “Guidance on Risk Assessment of Living Modified Organisms” this background material is relevant
  • 5. Risk assessment of living modified mosquitoes species that act as vectors of human and animal diseases
Additional Information
Type of resource
  • Article (journal / magazine / newspaper)
Identifier
DOI: 10.1126/science.287.5462.2474
Publisher and its location
American Association for the Advancement of Science
New York
Rights
© 2012 American Association for the Advancement of Science
Format
HTML
Source
Science
Keywords and any other relevant information
Citation: Science 31 March 2000 Vol. 287 no. 5462 pp. 2474-2476