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Record information and status
Record ID
103501
Status
Published
Date of creation
2012-05-14 13:28 UTC (dina.abdelhakim@cbd.int)
Date of publication
2012-05-14 13:28 UTC (dina.abdelhakim@cbd.int)

General Information
Title
Late-acting dominant lethal genetic systems and mosquito control
Author
Hoang Kim Phuc, Morten H Andreasen, Rosemary S Burton, Céline Vass, Matthew J Epton, Gavin Pape, Guoliang Fu, Kirsty C Condon, Sarah Scaife, Christl A Donnelly, Paul G Coleman, Helen White-Cooper and Luke Alphey
Author’s contact information
Luke Alphey
Email: luke.alphey@zoo.ox.ac.uk
Language(s)
  • English
Publication date
2007-03-20
Subject
Summary, abstract or table of contents
Abstract

Background: Reduction or elimination of vector populations will tend to reduce or eliminate transmission of vector-borne diseases. One potential method for environmentally-friendly, species-specific population control is the Sterile Insect Technique (SIT). SIT has not been widely used against insect disease vectors such as mosquitoes, in part because of various practical difficulties in rearing, sterilization and distribution. Additionally, vector populations with strong density-dependent effects will tend to be resistant to SIT-based control as the population-reducing effect of induced sterility will tend to be offset by reduced density-dependent mortality.

Results: We investigated by mathematical modeling the effect of manipulating the stage of development at which death occurs (lethal phase) in an SIT program against a density-dependence-limited insect population. We found late-acting lethality to be considerably more effective than early-acting lethality. No such strains of a vector insect have been described, so as a proof-of-principle we constructed a strain of the principal vector of the dengue and yellow fever viruses, Aedes (Stegomyia) aegypti, with the necessary properties of dominant, repressible, highly penetrant, late-acting lethality.

Conclusion: Conventional SIT induces early-acting (embryonic) lethality, but genetic methods potentially allow the lethal phase to be tailored to the program. For insects with strong density-dependence, we show that lethality after the density-dependent phase would be a considerable improvement over conventional methods. For density-dependent parameters estimated from field data for Aedes aegypti, the critical release ratio for population elimination is modeled to be 27% to 540% greater for early-acting rather than lateacting lethality. Our success in developing a mosquito strain with the key features that the modeling indicated were desirable demonstrates the feasibility of this approach for improved SIT for disease control.
Thematic areas
  • Scientific and technical issues
    • Risk assessment
Background material to the “Guidance on risk assessment of living modified organisms”
Is this document is recommend as background material for the “Guidance on Risk Assessment of Living Modified Organisms”
Yes
Section(s) of the “Guidance on Risk Assessment of Living Modified Organisms” this background material is relevant
  • 5. Risk assessment of living modified mosquitoes species that act as vectors of human and animal diseases
Additional Information
Type of resource
  • Article (journal / magazine / newspaper)
Identifier
doi:10.1186/1741-7007-5-11
Publisher and its location
BioMed Central (BMC)
Rights
© 2007 Phuc et al
Format
11 page PDF
Source
BMC Biology
Keywords and any other relevant information
Citation: BMC Biology 2007, 5:11