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Gene and DNA Sequence
Record information and status
Record ID
103553
Status
Published
Date of creation
2012-05-30 15:14 UTC (german_bch@bvl.bund.de)
Date of last update
2012-07-17 15:11 UTC (dina.abdelhakim@cbd.int)
Date of publication
2012-07-17 15:11 UTC (dina.abdelhakim@cbd.int)

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General information
Name of the gene or DNA sequence
Synthetic elastin-like protein
Abbreviation
CS-100xELP
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
Yes
Characteristics of the protein coding sequence
Name of the protein expressed by the coding sequence
elastin 100xELP
Biological function
Elastin is a structural protein found in mammals that confers elasticity to connective tissues. Examples for the function of elastin are the elasticity of big blood vessels such as the aorta or the dimensional stability of pulmonary alveolis. Elastin is made up of two domain types: A hydrophobic domain consisting of repeats of oligopeptides rich in glycin, alanine, valine and proline alternating with a hydrophilic domain that also incorporates lysine residues.

Soluble elastin is secreted by the cells and covalently linked by its lysine residues through an enzymatic process. Thereby an elastin-network is formed that is composed of elastic fibers and is able to be reversibly stretched for some of its own magnitudes.

The artificial elastin 100xELP has high similarity to human elastin and consists of oligomeric repeats of the pentapaptide Val-Pro-Gly-Xaa-Gly (Xaa - any amino acid but proline). Hence it solely consists of units that resemble the hydrophobic domain of natural elastin. Therefore it is not able to be linked to a network. However, 100xELP exhibits a good ability to be solved in aqueous solution depending on the salt concentration and temperature. It can undergo an inverse transition, i.e. the protein is soluble in an aqueous solution below its transition temperature but insoluble above this critical value.
Related trait(s) or use(s) in biotechnology
  • Production of medical or pharmaceutical compounds (human or animal)
  • Use in industrial applications
Additional Information

Records referencing this document (5)
IDDescription
5record(s) found
Country's Decision or any other Communication1 record
Modified Organism3 records
Risk Assessment1 record