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Modified Organism
Sorghum with modified levels of vitamin A, zinc and iron
Record information and status
Record ID
103628
Status
Published
Date of creation
2012-06-18 17:52 UTC (manoela.miranda@cbd.int)
Date of last update
2012-08-24 14:39 UTC (dina.abdelhakim@cbd.int)
Date of publication
2012-08-24 14:39 UTC (dina.abdelhakim@cbd.int)

Living Modified Organism identity
The image below identifies the LMO through its unique identifier, trade name and a link to this page of the BCH. Click on it to download a larger image on your computer. For help on how to use it go to the LMO quick-links page.

LMO name
Sorghum with modified levels of vitamin A, zinc and iron
Transformation event
ABS188
Developer(s)
Pioneer Hi-Bred International, Inc.
PO Box 1000
Johnston IA 50131-0184
USA
Phone:+1-515-270-3200
Fax:+1-515-334-4415
Description
Sorghum ABS188 was genetically modified through a transformation mediated by Agrobacterium to improve bioavailable levels of vitamin A, zinc and iron.

Gene LPA1 was inserted to reduce the synthesis of phytic acid which reduces sorghum's zinc and iron availability to human. Genes PSY1 and CRT1 were inserted in sorghum to synthesize phytoene synthetases and phytoene desaturase which are required for the synthesis of beta-carotene (vitamin A).
Recipient Organism or Parental Organisms
The term Recipient organism refers to an organism (either already modified or non-modified) that was subjected to genetic modification, whereas Parental organisms refers to those that were involved in cross breeding or cell fusion.
Sorghum bicolor - Sorghum
Characteristics of the transformation process
Techniques used for the modification
  • Agrobacterium-mediated DNA transfer
Introduced or modified genetic elements
Some of these genetic elements may be present as fragments or truncated forms. Please see notes below, where applicable.
Low Phytic Acid 1 - Sorghum bicolor - Sorghum
Changes in quality and/or metabolite content
Phytoene Synthase 1 gene - Zea mays - Maize, Corn, MAIZE
Changes in quality and/or metabolite content - Vitamins
Phytoene Desaturase gene - Erwinia uredovora - PANAN
Changes in quality and/or metabolite content - Vitamins
Phosphomannose Isomerase gene - Escherichia coli - ECOLX
Mannose tolerance
Selectable marker genes and reporter genes
27kD gamma-zein Promoter - Zea mays - Maize, Corn, MAIZE
Globulin 1 Promotor - Zea mays - Maize, Corn, MAIZE
Globulin 1 Terminator - Zea mays - Maize, Corn, MAIZE
Alcohol Dehydrogenase 1, intron 6 - Zea mays - Maize, Corn, MAIZE
Sorghum bicolor legumin protein Terminator - Sorghum bicolor - Sorghum
Beta-kafirin promoter - Sorghum bicolor - Sorghum
rbcS Transit Peptide - Pisum sativum - Garden pea, PEA
Beta-kafirin Terminator - Sorghum bicolor - Sorghum
Ubiquitin gene promoter - Zea mays - Maize, Corn, MAIZE
Ubiquitin Intron 1 - Zea mays - Maize, Corn, MAIZE
Proteinase inhibitor II gene terminator - Solanum tuberosum - Potato, SOLTU
Notes regarding the genetic elements introduced or modified in this LMO
Globulin 1 Promoter: Obtained from Zea mays strain PHP20926. The promoter sequence contains a base pair change and a base par addition at the 3' end to correct the ORF as follows: TATAAATGCGCG changed to TATAAATCCCGCG

Globulin 1 Terminator: Obtained from Zea mays strain PHP20926. The terminator sequence contains 2 base pair changes at the 5' end to expose an ORF. The sequence is as follows: GCTCGCCAAAA changed to GCTCGCTCAAA.
LMO characteristics
Modified traits
Common use(s)
  • Food
  • Feed
Additional Information
Other relevant website address or attached documents

Records referencing this document (2)
IDDescription
2record(s) found
Country's Decision or any other Communication1 record
Risk Assessment1 record