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Information Resource
Record information and status
Record ID
104995
Status
Published
Date of creation
2013-06-16 06:12 UTC (jack.heinemann@canterbury.ac.nz)
Date of last update
2013-08-01 11:35 UTC (jack.heinemann@canterbury.ac.nz)
Date of publication
2013-08-20 07:14 UTC (helmut.gaugitsch@umweltbundesamt.at)

General Information
Title
A long-term toxicology study on pigs fed a combined genetically modified (GM) soy and GM maize diet
Author
JudyJudy A. Carman, Howard R. Vlieger, Larry J. Ver Steeg, Verlyn E. Sneller, Garth W. Robinson, Catherine A. Clinch-Jones, Julie I. Haynes, John W. Edwards
Author’s contact information
Language(s)
  • English
Publication date
2013-06-07
Subject
Summary, abstract or table of contents
A significant number of genetically modified (GM) crops have been approved to enter
human food and animal feed since 1996, including crops containing several GM genes
'stacked' into the one plant. We randomised and fed isowean pigs (N=168) either a mixed
GM soy and GM corn (maize) diet (N=84) or an equivalent non-GM diet (N=84) in a longterm
toxicology study of 22.7 weeks (the normal lifespan of a commercial pig from
weaning to slaughter). Equal numbers of male and female pigs were present in each
group. The GM corn contained double and triple-stacked varieties. Feed intake, weight
gain, mortality and blood biochemistry were measured. Organ weights and pathology
were determined post-mortem. There were no differences between pigs fed the GM and
non-GM diets for feed intake, weight gain, mortality, and routine blood biochemistry
measurements. The GM diet was associated with gastric and uterine differences in pigs.
GM-fed pigs had uteri that were 25% heavier than non-GM fed pigs (p=0.025). GM-fed
pigs had a higher rate of severe stomach inflammation with a rate of 32% of GM-fed pigs
compared to 12% of non-GM-fed pigs (p=0.004). The severe stomach inflammation was
worse in GM-fed males compared to non-GM fed males by a factor of 4.0 (p=0.041), and
GM-fed females compared to non-GM fed females by a factor of 2.2 (p=0.034).
Thematic areas
Background material to the “Guidance on risk assessment of living modified organisms”
Is this document is recommend as background material for the “Guidance on Risk Assessment of Living Modified Organisms”
Yes
Section(s) of the “Guidance on Risk Assessment of Living Modified Organisms” this background material is relevant
  • 2. Risk assessment of living modified plants with stacked genes or traits
Information on Organisms or LMOs
Organism(s) identification
Zea mays - Maize, Corn, MAIZE
Glycine max - Soybean, Soya bean, Soya, SOYBN
LMO(s) identification
MON-ØØ863-5 x MON-ØØ81Ø-6 x MON-ØØ6Ø3-6 - Roundup Ready™ YieldGard™ maize
Resistance to antibiotics - Kanamycin Resistance to diseases and pests - Insects - Coleoptera (beetles), Lepidoptera (butterflies and moths) Resistance to herbicides - Glyphosate
Show detection method(s)
MON-ØØ6Ø3-6 x MON-ØØ81Ø-6 - Roundup Ready™ YieldGard™ maize
Resistance to diseases and pests - Insects - Lepidoptera (butterflies and moths) Resistance to herbicides - Glyphosate
Show detection method(s)
MON-ØØ6Ø3-6 - Roundup Ready™ maize
Resistance to herbicides - Glyphosate
Show detection method(s)
Additional Information
Type of resource
  • Article (journal / magazine / newspaper)
Identifier
ISSN 1177-4258
Publisher and its location
Journal of Organic Systems. Australia
Rights
Copyright held by authors. Article is open source.
Format
17 pages. Requires pdf reader for viewing.
Source
original document
Keywords and any other relevant information
GMO, GM corn, GM soy, GM animal feed, toxicology, stomach inflammation,
uterus weight
Access to the resource