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Modified Organism
Yeast modified for the production of Farnesene
Record information and status
Record ID
105207
Status
Published
Date of creation
2014-01-23 19:33 UTC (gutemberg.sousa@mctic.gov.br)
Date of last update
2014-01-27 20:05 UTC (dina.abdelhakim@cbd.int)
Date of publication
2014-01-27 20:05 UTC (dina.abdelhakim@cbd.int)

Living Modified Organism identity
The image below identifies the LMO through its unique identifier, trade name and a link to this page of the BCH. Click on it to download a larger image on your computer. For help on how to use it go to the LMO quick-links page.

LMO name
Yeast modified for the production of Farnesene
Transformation event
Y1979-Farnasene
Developer(s)
Dr Odair Glavina
President of CIBio
Amyris Brasil S.A. (Amyris)
Rua James Clerk Maxwell, 315 - Techno Park
Campinas, São Paulo
Brazil, 13069-380
Phone:55 19 37839457
Fax:55 19 37839450
Email:glavina@amyris.com
Description
The Y1979 strain of yeast was transformed with the insertion of the coding sequence for Farnesene Synthase to produce beta-farnesene from the fermentation of sugar cane. This is a long chain hydrocarbon that can be used as a biofuel.
Recipient Organism or Parental Organisms
The term Recipient organism refers to an organism (either already modified or non-modified) that was subjected to genetic modification, whereas Parental organisms refers to those that were involved in cross breeding or cell fusion.
Saccharomyces cerevisiae - Yeast, YEASX
Point of collection or acquisition of the recipient organism
Strain Y1979 derived from PE-2
Characteristics of the transformation process
Introduced or modified genetic elements
Some of these genetic elements may be present as fragments or truncated forms. Please see notes below, where applicable.
Farnesene Synthase gene - Artemisia annua - Artemisia , Sweet Wormwood, Sweet Annie, Sweet Sagewort, Annual Wormwood
Use in industrial applications - Biofuel production
Notes regarding the genetic elements introduced or modified in this LMO
Modified S. cerevisiae developed through a framework of the modular construction of integration cassettes that are propagated in Escherichia coli.
LMO characteristics
Modified traits
Common use(s)
  • Biofuel
Additional Information
Additional Information
Saccharomyces cerevisiae strain Y1979 is in a diploid state, resulting in the blocking of sexual reporoduction between the haploid forms α and a. Additionally, genes STE5 and IME1, which are required for sporulation and for early sporulation-specific genes expression, were inactivated in this strain therefore hindering production of haploid ascospores and reducing to insignificant levels the likelihood that the yeast sexually reproduces with other naturally occurring yeasts, including laboratory lineages.

These modifications, coupled with alterations to the mevalonate pathway, make this strain highly dependent on specific conditions for proliferation and maintenance, warranting difficulty for the organism in colonizing the environment by invasion or competition with the natural microbiota.

Records referencing this document (2)
IDDescription
2record(s) found
Country's Decision or any other Communication1 record
Risk Assessment1 record