Modified melittin peptide coding sequence

CS-MsrA1-SYNTH

Modified melittin peptide

Melittin, a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. It is water-soluble as a tetramer, but it spontaneously integrates into lipid bilayers and is thought to act as a cytolytic and channel-forming antimicrobial peptide.

This modified MsrA1 peptide is a synthetic molecule designed through molecular modelling. It includes the eight N-terminal amino acids of cecropin A from Hyalophora cecropia (Northern Silkworm) caterpillars and the eighteen C-terminal  amino acids of melittin from Apis mellifera (Western Honey Bee), as well as two additional positively-charged amino acid residues at the C-terminus of the molecule, and an additional Met-Ala-Leu-Glu-His sequence at the N-terminus of the molecule.