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Gene and DNA Sequence
Record information and status
Record ID
106333
Status
Published
Date of creation
2015-01-30 09:07 UTC (g.mozgova@yandex.ru)
Date of publication
2015-01-30 22:23 UTC (dina.abdelhakim@cbd.int)

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General information
Name of the gene or DNA sequence
Modified melittin peptide coding sequence
Abbreviation
CS-MsrA1-SYNTH
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
Yes
Characteristics of the protein coding sequence
Name of the protein expressed by the coding sequence
Modified melittin peptide
Biological function
Melittin, a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. It is water-soluble as a tetramer, but it spontaneously integrates into lipid bilayers and is thought to act as a cytolytic and channel-forming antimicrobial peptide.
Related trait(s) or use(s) in biotechnology
Additional Information
Additional Information
This modified MsrA1 peptide is a synthetic molecule designed through molecular modelling. It includes the eight N-terminal amino acids of cecropin A from Hyalophora cecropia (Northern Silkworm) caterpillars and the eighteen C-terminal  amino acids of melittin from Apis mellifera (Western Honey Bee), as well as two additional positively-charged amino acid residues at the C-terminus of the molecule, and an additional Met-Ala-Leu-Glu-His sequence at the N-terminus of the molecule.

Records referencing this document (1)
IDDescription
1record(s) found
Modified Organism1 record