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Genetic element
(GENE)
last updated: 24 Mar 2015
CoA-transferase beta subunit gene
EN
CS-ipdB-RHOE1
EN
Protein coding sequence
No
-
BCH-ORGA-SCBD-107871-2 Organism Rhodococcus equi (RHOE1)Bacteria
EN
IpdB - CoA-transferase beta subunit
EN
The gene ipdB (REQ_07160) is an ortholog of rv3552 of Mycobacterium tuberculosis and likewise localized in the cholesterol catabolic gene cluster of its bacterial chromosome of Rhodococcus equi. The encoded protein IpdB (GenBank accession CBH46833) carries a COG2057 signature of AtoA, the beta subunit acetoacetyl-CoA transferase of E. coli. It is thought that IpdB is an beta subunit of a heterodimeric coenzyme A transferase involved in steroid catabolism, more specific in methylhexahydroindanone propionate degradation. It was shown that the cholesterol catabolism is important for pathogenicity of R. equi.
EN
EN
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