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Gene and DNA Sequence
Record information and status
Record ID
Date of creation
2015-05-15 12:22 UTC (g.mozgova@yandex.ru)
Date of publication
2015-05-26 18:01 UTC (dina.abdelhakim@cbd.int)

General information
Name of the gene or DNA sequence
Recombinant human lactoferrin coding sequence
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
Donor organism
Donor organism
Homo sapiens - HUMAN
Characteristics of the protein coding sequence
Name of the protein expressed by the coding sequence
Recombinant human lactoferrin
Biological function
Lactoferrin is an iron-binding glycoprotein of the transferrin family, first isolated from milk but also found in most exocrine secretions as well as in the secondary granules of neutrophils. The many reports on its antimicrobial and antiinflammatory activityin vitro identify lactoferrin as important in host defense against infection and excessive inflammation. Most if not all lactoferrin actions are mediated through iron sequestration and/or interaction with a large variety of ligands including microbial cell wall components and cellular receptors, through its highly positively charged N-terminus. Lactoferrin exerts its effects on glandular epithelia, secretions, mucosal surfaces as well as in the interstitium and vascular compartments where it has been postulated to participate in iron metabolism, disease defense, and modulation of inflammatory and immune responses.
Related trait(s) or use(s) in biotechnology
  • Production of medical or pharmaceutical compounds (human or animal)

Records referencing this document (3)
3record(s) found
Modified Organism1 record
Risk Assessment2 records