Rubber tree modified to express the scFv4715 antibody fragment | BCH-LMO-SCBD-108912 | Living Modified Organism | Biosafety Clearing-House
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Living Modified Organism (LMO)
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Decisions on the LMO Risk Assessments  
last updated: 18 Sep 2015
Living Modified Organism identity
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Rubber tree modified to express the scFv4715 antibody fragment
EN
HT2
No
Hevea brasiliensis was modified to express the scFv4715 recombinant antibody, which is intended to bind to S. gordonii coat protein, the causal agent of dental plaque/cavity, with the aim to prevent tooth decay. Expression of the scFv4715 gene in Hevea brasiliensis allows for the commercial production of this protein for pharmaceutical purposes.

Hevea with scFv4715 also harbours nptII gene that confers resistance to kanamycin, which was incorporated in the growth media to select transformed callus after co-cultivation with Agrobacterium.
EN
The term “Recipient organism” refers to an organism (either already modified or non-modified) that was subjected to genetic modification, whereas “Parental organisms” refers to those that were involved in cross breeding or cell fusion.
Clone GL1
EN
Characteristics of the modification process
pGPTV-Kan
EN
  • Agrobacterium-mediated DNA transfer
Some of these genetic elements may be present as fragments or truncated forms. Please see notes below, where applicable.
  • BCH-GENE-SCBD-108285-2 Coding sequence of scFv4715 antibody | Mus musculus (Mouse, House mouse, MOUSE)
    Protein coding sequence | Production of medical or pharmaceutical compounds (human or animal) (Antibodies and antigens)
  • BCH-GENE-SCBD-100287-7 CaMV 35S promoter | Cauliflower mosaic virus (CaMV)
    Promoter
  • BCH-GENE-SCBD-100269-8 Nopaline Synthase Gene Terminator | Agrobacterium tumefaciens (Agrobacterium)
    Terminator
  • BCH-GENE-SCBD-100270-6 Nopaline Synthase Gene Promoter | Agrobacterium tumefaciens (Agrobacterium)
    Promoter
  • BCH-GENE-SCBD-15001-5 Neomycin Phosphotransferase II | Escherichia coli (ECOLX)
    Protein coding sequence | Resistance to antibiotics (Kanamycin)
  • BCH-GENE-SCBD-103067-9 Transcript 7 gene 3' untranslated region | Agrobacterium tumefaciens (Agrobacterium)
    Terminator
  • BCH-GENE-SCBD-108910-1 Pathogenesis-related protein 1a signal peptide | Nicotiana tabacum (Tobacco, TOBAC )
    Transit signal
  • BCH-GENE-SCBD-108911-1 FLAG Tag
    Transit signal
The inserted genetic material is the region between the left boarder and the right boarder (T-DNA) from the Ti plasmid of Agrobacterium tumefaciens harbouring the above described gene construct.
EN
LMO characteristics
EN
  • Pharmaceutical
  • Research
Detection method(s)
EN
Additional Information
EN
Records referencing this document Show in search
Record type Field Record(s)
Risk Assessment generated by a regulatory process Living modified organism(s) 1
Country's Decision or any other Communication Living modified organism(s) 1

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