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Risk Assessment
Record information and status
Record ID
109791
Status
Published
Date of creation
2016-03-11 09:36 UTC (ralphklapps@gmail.com)
Date of publication
2016-03-14 02:18 UTC (estaciojulietafe@gmail.com)

General Information
Country
  • Philippines
Title of risk assessment
Determination of the Safety of Monsanto's Corn MON 87427 For Direct use as Food, Feed, and for Processing
Date of the risk assessment
2014-11-28
Institution responsible for the risk assessment
Department of Agriculture
Elliptical Road, Diliman
Quezon City
Philippines, 1100
Phone:+632 920-3986,+632 924-1278 local 2802
Fax:+632 920-3986
Email:osec.da@gmail.com
Url:DA
Contact details of the main responsible risk assessor
Ms. Merle B. Palacpac
Chief
Post Entry Quarantine Station
Bureau of Plant Industry (BPI)
Economic Garden
Los Banos, Laguna
Philippines, 4030
Phone:+63 49 536 1678
Fax:+63 49 536 1678
Email:merle.palacpac@gmail.com
Url:http://bpi.da.gov.ph
Risk assessment details
Living modified organism
MON-87427-7 - Maize modified for tissue selective glyphosate tolerance
Resistance to herbicides - Glyphosate
Show detection method(s)
Scope of the risk assessment
  • LMOs for direct use as feed
  • LMOs for direct use as food
  • LMOs for processing
Risk assessment report / Summary
Methodology and points to consider
Likelihood that the potential adverse effects will be realized
The MON 87427- produced CP4EPSPS protein and the E. coli-produced CP4EPSPS protein was shown to be biochemically, structurally, and functionally equivalent. Western blot analysis confirmed the greater than 98% of the E.coli produced CP4EPSPS was digested in SGF within 15 seconds. In summary, the results of these experiments confirmed that the E coli produced CP4EPSPS proteins was rapidly digested after incubation in SGF and is therefore unlikely to pose a human health concern.
Possible consequences:
Corn grain contains two main anti-nutrients: phytic acid and  raffinose.  Phytic acid is present in corn grain, where it chelates mineral nutrients including calcium, magnesium, potassium, iron and zinc rendering them biologically unavailable to monogastric animals consuming the grain. Raffinose is a low molecular weight non-digestible carbohydrate present in corn grain that is considered to be an anti nutrient due to the gas production and resulting flatulence caused by consumption (Liener, 2000).
Estimation of the overall risk
Corn MON 87427 is found substantially equivalent to conventional counterpart and does not pose any significant risk to animal and human health.
Recommendation(s)
A biosafety permit for Corn MON 87427 and all progenies derived from crosses of the product with any conventionally-bred corn and corn containing approved-biotech events for direct use as food, feed and for processing was issued to Monsanto Philippines Inc. Corn MON 87427 is found substantially equivalent to conventional counterpart and does not pose any significant risk to animal and human health.
Need(s) for further information on specific issues of concern
Corn MON 87427 is found substantially equivalent to conventional counterpart and does not pose any significant risk to animal and human health.
Receiving environment(s) considered
This application is not for propagation of the Corn MON 87427. This LMO will be directly used for food, feed and for processing.
LMO detection and identification methods proposed
Quantitative diagnostic lateral flow strips, ELISA and PCR for routine quantitative and semi-quantitative detection of transgenes.  For higher sensitivity, real-time PCR may be used.
Additional Information
Additional Information
Corn MON 87427 is intended for direct use as food, feed and for processing.

All relevant references submitted by the technology developer in their application; other references requested by the Scientific and Technical Review Panel (STRP) members and DA Regulatory Agencies during the evaluation of this event.
Other relevant website address or attached documents

Records referencing this document (1)
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