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Organism
Record information and status
Record ID
110712
Status
Published
Date of creation
2016-08-01 16:59 UTC (dina.abdelhakim@cbd.int)
Date of publication
2016-08-01 16:59 UTC (dina.abdelhakim@cbd.int)

Organism information
Scientific name
Bovine viral diarrhea virus 2
Taxonomic Classification
FamilyFlaviviridae
GenusPestivirus
SpeciesBovine viral diarrhea virus 2
Common name(s)
BVDV-2
Additional Classification
Type of organism
  • Viruses
Characteristics related to biosafety
Geographical distribution
Bovine Viral Diarrhea (BVD) is a significant economic disease of cattle which is endemic in the majority of countries throughout the world. The causative agent, bovine viral diarrhea virus (BVDV) is a member of the Pestivirus genus of the family Flaviviridae.
Known pathogenicity and/or allergenicity
BVD infection results in a wide variety of clinical signs, due to its immunosuppressive effects, as well as having a direct effect on respiratory disease and fertility.

Following viral entry and contact with the mucosal lining of the mouth or nose, replication occurs in epithelial cells. BVDV replication has a predilection for the palatine tonsils, lymphoid tissues and epithelium of the oropharynx.

Phagocytes take up BVDV or virus-infected cells and transport them to peripheral lymphoid tissues; the virus can also spread systemically through the bloodstream. Viraemia occurs 2-4 days after exposure and virus isolation from serum or leukocytes is generally possible between 3-10 days post infection

During systemic spread the virus is able to gain entry into most tissues with a preference for lymphoid tissues. Neutralising antibodies can be detected from 10-14 days post infection with titres continuing to increase slowly for 8-10 weeks. After 2-3 weeks, antibodies effectively neutralise viral particles, promote clearance of virus and prevent seeding of target organs
Common use(s)
  • Vaccine
Additional Information
Additional Information
The virus genome is positive-strand RNA that is translated to form a single virus polyprotein, which, through cleavage by both host and virus proteases, gives rise to either 11 or 12 mature viral proteins (NH2-Npro-C-Erns-E1-E2-p7-NS2-NS3-NS4A-NS4B-NS5A-NS5B-COOH), dependent on the virus biotype
Other relevant website address or attached documents

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