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Gene and DNA Sequence
Record information and status
Record ID
111062
Status
Published
Date of creation
2016-10-17 19:49 UTC (zuzana.doubkova@mzp.cz)
Date of publication
2016-10-25 17:55 UTC (dina.abdelhakim@cbd.int)

General information
Name of the gene or DNA sequence
Heat-labile enterotoxin, B subunit gene
Abbreviation
CS-LTB-ECOLX
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
No
Donor organism
Donor organism
Escherichia coli - ECOLX
Characteristics of the protein coding sequence
Name of the protein expressed by the coding sequence
Heat-labile enterotoxin, B subunit
Biological function
Heat-labile enterotoxin (LT) is a hetero-oligomeric AB 5 type enterotoxin composed of a 27 kDa A subunit with toxic ADP ribosyl transferase activity and a stable noncovalent-linked pentamer of 11.6 kDa B subunits.

The B subunit pentamer mediates holotoxin binding to ganglioside GM1 on intestinal epithelial cells, with lower affinity for GD1B, asialoGM1 and lactosylceramide gangliosides.
Related trait(s) or use(s) in biotechnology

Records referencing this document (1)
IDDescription
1record(s) found
Modified Organism1 record