Potato plans were modified to constitutively express
2-deoxyglucose-6-phosphate phosphatase (DOGR1) gene from
Saccharomyces cerevisiae.
The function of the DOGR1 is the dephosphorylation of
2-deoxyglucose-6-phosphate in the transformed plant cells,
therefore inhibiting its competitiveness with glucose-6-phosphate,
which would cause cell death through the inhibition of glycolysis,
protein synthesis, cell wall polysaccharide synthesis and also
protein glycosylation.
Therefore, as a result of the genetic modification, the plant cells
are tolerant to 2-deoxyglucose in the growth medium.
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