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Gene and DNA Sequence
Record information and status
Record ID
114715
Status
Published
Date of creation
2019-05-21 16:34 UTC (austein.mcloughlin@cbd.int)
Date of publication
2019-05-21 16:34 UTC (austein.mcloughlin@cbd.int)

General information
Name of the gene or DNA sequence
Nonstructural protein 1
Abbreviation
NS1
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
No
Donor organism
Donor organism
Yellow fever virus - YFV 17D
Donor organism point of collection
Yellow fever virus strain 17D (vaccine strain)
Characteristics of the protein coding sequence
Biological function
Nonstructural protein 1 (NS1) plays an essential role in immune evasion, pathogenesis, and viral replication. NS1 is required for the formation of the replication complex and recruitment of other nonstructural proteins to the endoplasmic reticulum. NS1 also travels to the plasma membrane, where it is excrete as a lipoparticle and binds to macrophages and dendritic cells. NS1 inhibits Toll-like receptor 3 signal transduction.
Additional Information
Other relevant website address or attached documents

Records referencing this document (3)
IDDescription
3record(s) found
Country's Decision or any other Communication1 record
Modified Organism1 record
Risk Assessment1 record