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Gene and DNA Sequence
Record information and status
Record ID
115116
Status
Published
Date of creation
2019-08-19 15:20 UTC (austein.mcloughlin@cbd.int)
Date of last update
2019-08-19 16:55 UTC (austein.mcloughlin@cbd.int)
Date of publication
2019-08-19 16:55 UTC (austein.mcloughlin@cbd.int)

General information
Name of the gene or DNA sequence
ATR serine/threonine kinase
Alternate Genetic Element Name (synonyms)
ATM and Rad3-related
Abbreviation
ATR
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
No
Donor organism
Donor organism
Zea mays - Maize, Corn, MAIZE
Characteristics of the protein coding sequence
Biological function
Serine/threonine-protein kinase ATR (ATR) catalyzes the addition of a phosphorate to serine or threonine residues. The protein plays a central role in cell-cycle regulation at the G2 phase checkpoint in response to single stranded DNA, DNA damage, and/or a replication block, but is not required for G2-arrest. This protein functions by transmitting DNA damage signals to downstream effectors of cell-cycle progression. Research has suggested that ATR may phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage to regulate the DNA damage response mechanism.

ATR is also required for the basal expression of RNR1 (ribonucleotide reductase large subunit) and for effective immune responses that involve the activation of DNA damage responses, as well as acting with telomerase to maintain telomeric DNA tracts. However, ATR is not required for telomere length homeostasis.
Related trait(s) or use(s) in biotechnology
  • Sensitivity to DNA damaging agents
  • Impaired DNA repair

Records referencing this document (3)
IDDescription
3record(s) found
Modified Organism3 records