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Gene and DNA Sequence
Record information and status
Record ID
115117
Status
Published
Date of creation
2019-08-19 15:43 UTC (austein.mcloughlin@cbd.int)
Date of last update
2019-08-19 16:55 UTC (austein.mcloughlin@cbd.int)
Date of publication
2019-08-19 16:55 UTC (austein.mcloughlin@cbd.int)

General information
Name of the gene or DNA sequence
ATM protein kinase
Abbreviation
ATM
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
No
Donor organism
Donor organism
Zea mays - Maize, Corn, MAIZE
Characteristics of the protein coding sequence
Name of the protein expressed by the coding sequence
ATAXIA-TELANGIECTASIA MUTATED
Biological function
ATAXIA-TELANGIECTASIA MUTATED (ATM) is a serine/threonine protein kinase that catalyzes the addition of a phosphate group to serine or threonine residues and is activated upon perception of genotoxic stresses (e.g. ionizing radiation). ATM primarily responds to double stranded DNA breaks. The kinase phosphorylates histone variant H2AX to form H2AXS139ph at double strand breaks. The protein becomes activated in response to stress-induced damage in somatic cells and DNA damage during meiosis. ATM has also been implicated in cellular responses to telomere dysfunction. ATM works synergistically with RUG3 during the DNA damage response.
Related trait(s) or use(s) in biotechnology
  • Sensitivity to DNA damaging agents
  • Impaired DNA repair mechanisms

Records referencing this document (1)
IDDescription
1record(s) found
Modified Organism1 record