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Modified Organism
Vectormune® AI
Record information and status
Record ID
115564
Status
Published
Date of creation
2020-04-13 13:00 UTC (gutemberg.sousa@mctic.gov.br)
Date of publication
2020-04-28 14:38 UTC (austein.mcloughlin@cbd.int)

Living Modified Organism identity
The image below identifies the LMO through its unique identifier, trade name and a link to this page of the BCH. Click on it to download a larger image on your computer. For help on how to use it go to the LMO quick-links page.

LMO name
Vectormune® AI
Transformation event
N/A
Developer(s)
Dr Alexis Henry Gaetan Goux
President of CIBio
Ceva Saúde Animal Ltda (CEVA)
Rua Manuel Joaquim Filho, 303 Pulínia - SP
Paulínia, São Paulo
Brazil, 13140-000
Phone:551938337700
Fax:55193833-7722
Email:alexisgoux@ceva.com
Url:CEVA
Description
The Vectormune® AI poultry vaccine is based on a Marek's Disease virus strain FC-126 (HVT FC-126), which is a non-pathogenic serotype of turkey herpesvirus (HVT), which is commonly used as a vaccine strain. The recombinant, modified virus expresses the H5 subtype of the hemagglutinin (HA) protein of the Avian Influenza virus (AIV). The vaccine is expected to confer protection to Avian influenza, which is a major respiratory disease in poultry.
Recipient Organism or Parental Organisms
The term Recipient organism refers to an organism (either already modified or non-modified) that was subjected to genetic modification, whereas Parental organisms refers to those that were involved in cross breeding or cell fusion.
Meleagrid herpesvirus 1 - Turkey Herpesvirus
Point of collection or acquisition of the recipient organism
Turkey Herpesvirus (HVT) strain FC-126
Characteristics of the transformation process
Vector
rHVT/AI
Techniques used for the modification
  • Homologus recombination
Introduced or modified genetic elements
Some of these genetic elements may be present as fragments or truncated forms. Please see notes below, where applicable.
Hemagglutinin gene - Influenza A virus - Influenza, Flu, Avian flu, Human flu, Swine influenza, Equine influenza, Bird flu
Production of medical or pharmaceutical compounds (human or animal) - Vaccines
Notes regarding the genetic elements introduced or modified in this LMO
The biological agent, called rHVT / AI, contains a recombinant turkey herpesvirus (HVT), which expresses the hemagglutinin (HA) protein (H5 subtype) of the Avian Influenza virus (AIV). The HA gene is under control of the Cytomegalovirus promoter and was inserted into an intergenic non-coding region of the HVT genome.

The inserted donor DNA fragment was obtained through amplifying the HA gene (H5 subtype) from the single-stranded RNA genome of the AIV using polymerase reverse transcriptase (RT-PCR) chain reaction. The AIV HA gene is expected to be expressed in several recombinants. This gene is also used in a similar avian yaws-influenza vector vaccine, which is licensed by the USDA.
LMO characteristics
Modified traits
Common use(s)
  • Vaccine