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Gene and DNA Sequence
Record information and status
Record ID
115567
Status
Published
Date of creation
2020-05-04 13:32 UTC (austein.mcloughlin@cbd.int)
Date of last update
2020-05-08 20:36 UTC (austein.mcloughlin@cbd.int)
Date of publication
2020-05-08 20:36 UTC (austein.mcloughlin@cbd.int)

General information
Name of the gene or DNA sequence
Nonstructural protein 1
Abbreviation
NS1
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
No
Donor organism
Donor organism
Influenza A virus - Influenza, Flu, Avian flu, Human flu, Swine influenza, Equine influenza, Bird flu
Additional Information
Additional Information
Nonstructural protein 1 (NS1) is an antagonist of the host cellular anti-viral dsRNA mediated responses and the activation of interferon genes. The protein also regulates gene expression by preventing the export of mRNA into the cytoplasm through the suppression of 3' processing of the pre-mRNA. Therefore, host cellular protein synthesis is turned off. Viral mRNAs are not affected as the viral polymerase produces the 3' poly(A) tail. Research has also suggested that NS1 induces nucleolar stress through epigenetic alterations of rDNA promoters.

Records referencing this document (1)
IDDescription
1record(s) found
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