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Genetic element
(GENE)
last updated: 06 May 2020
Polymerase acidic protein
EN
PA
EN
Protein coding sequence
No
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BCH-ORGA-SCBD-45782-7 Organism Influenza A virus (Influenza, Flu, Avian flu, Human flu, Swine influenza, Equine influenza, Bird flu)Viruses
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The polymerase acidic protein (PA) complexes with polymerase basic protein 1 and 2 to form an RNA-dependent RNA polymerase. PA is essential for the formation of the RNA polymerase and for viral replication. The complex primes transcription of viral RNA through a mechanism termed cap snatching, where the 5' ends (10 to 15 nucleotides) of host pre-mRNAs are removed. PA is thought to act as the endonuclease that cleaves the host pre-mRNAs. It was also suggested that PA can induce proteolytic degradation of co-expressed proteins.
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- UniProtKB - Polymerase acidic protein [ English ]
- The Polymerase Acidic Protein Gene of Influenza A Virus Contributes to Pathogenicity in a Mouse Model.pdf [ English ]
- PA Subunit from Influenza Virus Polymerase Complex Interacts with a Cellular Protein with Homology to a Family of Transcriptional Activators.pdf [ English ]
- Influenza A Virus Polymerase- Structural Insights into Replication and Host Adaptation Mechanisms.pdf [ English ]
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