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Gene and DNA Sequence
Record information and status
Record ID
115568
Status
Published
Date of creation
2020-05-06 13:42 UTC (austein.mcloughlin@cbd.int)
Date of publication
2020-05-06 13:42 UTC (austein.mcloughlin@cbd.int)

General information
Name of the gene or DNA sequence
Polymerase acidic protein
Abbreviation
PA
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
No
Donor organism
Donor organism
Influenza A virus - Influenza, Flu, Avian flu, Human flu, Swine influenza, Equine influenza, Bird flu
Characteristics of the protein coding sequence
Biological function
The polymerase acidic protein (PA) complexes with polymerase basic protein 1 and 2 to form an RNA-dependent RNA polymerase. PA is essential for the formation of the RNA polymerase and for viral replication. The complex primes transcription of viral RNA through a mechanism termed cap snatching, where the 5' ends (10 to 15 nucleotides) of host pre-mRNAs are removed. PA is thought to act as the endonuclease that cleaves the host pre-mRNAs. It was also suggested that PA can induce proteolytic degradation of co-expressed proteins.

Records referencing this document (1)
IDDescription
1record(s) found
Modified Organism1 record