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Gene and DNA Sequence
Record information and status
Record ID
115569
Status
Published
Date of creation
2020-05-06 14:14 UTC (austein.mcloughlin@cbd.int)
Date of publication
2020-05-06 14:14 UTC (austein.mcloughlin@cbd.int)

General information
Name of the gene or DNA sequence
Polymerase basic protein 1
Abbreviation
PB1
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
No
Donor organism
Donor organism
Influenza A virus - Influenza, Flu, Avian flu, Human flu, Swine influenza, Equine influenza, Bird flu
Characteristics of the protein coding sequence
Biological function
Polymerase basic protein 1 (PB1) complexes with polymerase acidic protein (PA) and polymerase basic protein 2 to form an RNA-dependent RNA polymerase. Transcription of viral mRNA occurs through a mechanism termed cap snatching, where the 5' methylated end (10 to 15 nucleotides) of the host pre-mRNAs is cleaved by PA and used for viral transcription. PB1 comprises the catalytic core of the polymerase and is responsible for RNA synthesis activity. PB1 uses the short sequences cleaved by PA for priming and initiating RNA synthesis.

Records referencing this document (1)
IDDescription
1record(s) found
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