Record details

General information

Name of the gene or DNA sequence

Polymerase basic protein 2

Abbreviation

PB2

Category of DNA sequence

Protein coding sequence

Is the gene / DNA sequence is a synthetic molecule?

Donor organism

Record #45782

Influenza A virus - Influenza, Flu, Avian flu, Human flu, Swine influenza, Equine influenza, Bird flu

Characteristics of the protein coding sequence

Biological function

Polymerase basic protein 2 (PB2) complexes with polymerase basic protein 1 and polymerase acidic protein (PA) to form an RNA-dependent RNA polymerase complex. During transcription, PB2 binds the 5′,7-methylguanosine cap of the host pre-mRNA, which will be subsequently cleaved by PA. PB2 also inhibits type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signalling protein MAVS.

Additional Information

Research has suggested that 627 position in the PB2 has been implicated in increased replication or virulence of avian influenza viruses in mammals and transmission among humans.

Other relevant website address or attached documents

UniProtKB - PB2

Influenza A Virus Polymerase- Structural Insights into Replication and Host Adaptation Mechanisms.pdf

Scoring amino acid mutation to predict pandemic risk of avian influenza virus.pdf

Amino Acid Substitutions in Polymerase Basic Protein 2 Gene Contribute to the Pathogenicity of the Novel A H7N9 Influenza Virus in Mammalian Hosts.pdf

The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon.pdf