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Record details
Gene and DNA Sequence
Record information and status
Record ID
115570
Status
Published
Date of creation
2020-05-06 14:42 UTC (austein.mcloughlin@cbd.int)
Date of publication
2020-05-06 14:42 UTC (austein.mcloughlin@cbd.int)
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General information
Name of the gene or DNA sequence
Polymerase basic protein 2
Abbreviation
PB2
Category of DNA sequence
Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
No
Donor organism
Donor organism
Record #45782
Influenza A virus - Influenza, Flu, Avian flu, Human flu, Swine influenza, Equine influenza, Bird flu
Characteristics of the protein coding sequence
Biological function
Polymerase basic protein 2 (PB2) complexes with polymerase basic protein 1 and polymerase acidic protein (PA) to form an RNA-dependent RNA polymerase complex. During transcription, PB2 binds the 5′,7-methylguanosine cap of the host pre-mRNA, which will be subsequently cleaved by PA. PB2 also inhibits type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signalling protein MAVS.
Additional Information
Additional Information
Research has suggested that 627 position in the PB2 has been implicated in increased replication or virulence of avian influenza viruses in mammals and transmission among humans.
Other relevant website address or attached documents
UniProtKB - PB2
Influenza A Virus Polymerase- Structural Insights into Replication and Host Adaptation Mechanisms.pdf
Scoring amino acid mutation to predict pandemic risk of avian influenza virus.pdf
Amino Acid Substitutions in Polymerase Basic Protein 2 Gene Contribute to the Pathogenicity of the Novel A H7N9 Influenza Virus in Mammalian Hosts.pdf
The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon.pdf
Records referencing this document
(
1
)
ID
Description
1
record(s) found
Modified Organism
1 record
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