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Gene and DNA Sequence
Record information and status
Record ID
115570
Status
Published
Date of creation
2020-05-06 14:42 UTC (austein.mcloughlin@cbd.int)
Date of publication
2020-05-06 14:42 UTC (austein.mcloughlin@cbd.int)

General information
Name of the gene or DNA sequence
Polymerase basic protein 2
Abbreviation
PB2
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
No
Donor organism
Donor organism
Influenza A virus - Influenza, Flu, Avian flu, Human flu, Swine influenza, Equine influenza, Bird flu
Characteristics of the protein coding sequence
Biological function
Polymerase basic protein 2 (PB2) complexes with polymerase basic protein 1 and polymerase acidic protein (PA) to form an RNA-dependent RNA polymerase complex. During transcription, PB2 binds the 5′,7-methylguanosine cap of the host pre-mRNA, which will be subsequently cleaved by PA. PB2 also inhibits type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signalling protein MAVS.

Records referencing this document (1)
IDDescription
1record(s) found
Modified Organism1 record