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Gene and DNA Sequence
Record information and status
Record ID
115582
Status
Published
Date of creation
2020-05-08 19:37 UTC (austein.mcloughlin@cbd.int)
Date of last update
2020-05-08 20:08 UTC (austein.mcloughlin@cbd.int)
Date of publication
2020-05-08 20:08 UTC (austein.mcloughlin@cbd.int)

General information
Name of the gene or DNA sequence
Polymerase I terminator
Alternate Genetic Element Name (synonyms)
rDNA terminator
Murine terminator
Abbreviation
T-polI
Category of DNA sequence
  • Terminator
Is the gene / DNA sequence is a synthetic molecule?
No
Donor organism
Donor organism
Mus musculus - Mouse, House mouse, MOUSE
Additional Information
Additional Information
Mouse polymerase I terminator contains the necessary sequences to end the transcription of rDNA. It is important to note that unlike protein-coding genes, which are transcribed by RNA polymerase II, rRNA transcripts do not have a polyadenylated tail. Polyadenylation of rRNA can signal for degradation. Thus, polymerase I promoter and terminator are used to produce viral genomes that do not require polyadenylated tails (e.g. the negative-sense RNA segments of the influenza genome). Mouse RNA Pol I terminator is often chosen as it generates precise 3' ends of transcripts, which is important for viral genomic RNA.

Records referencing this document (1)
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