Mouse polymerase I terminator contains the necessary sequences to
end the transcription of rDNA. It is important to note that unlike
protein-coding genes, which are transcribed by RNA polymerase II,
rRNA transcripts do not have a polyadenylated tail. Polyadenylation
of rRNA can signal for degradation. Thus, polymerase I promoter and
terminator are used to produce viral genomes that do not require
polyadenylated tails (e.g. the negative-sense RNA segments of the
influenza genome). Mouse RNA Pol I terminator is often chosen as it
generates precise 3' ends of transcripts, which is important for
viral genomic RNA.
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