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Gene and DNA Sequence
Record information and status
Record ID
115609
Status
Published
Date of creation
2020-06-16 10:02 UTC (jnjagi@biosafetykenya.go.ke)
Date of publication
2020-06-17 18:53 UTC (austein.mcloughlin@cbd.int)

General information
Name of the gene or DNA sequence
Major immediate early promoter containing intron A
Alternate Genetic Element Name (synonyms)
LP
Abbreviation
P-IE
Category of DNA sequence
  • Promoter
Is the gene / DNA sequence is a synthetic molecule?
No
Donor organism
Donor organism
Human betaherpesvirus 5 - Human cytomegalovirus, HCMV, HHV-5
Additional Information
Additional Information
The  human cytomegalovirus immediate-early promoter containing intron A  promotes high levels of transcription in animal systems. The inclusion of intron further further enhances transcription compared to the immediate-early promoter alone (15 times higher; human embryonic kidney cells). This promoter-intron system has previously been deployed in vaccine research.

From Sridhar et al. (2008) the following portions are found within this sequence:
Regulatory sequence = 437 bp
Enhancer = 481 bp
Promoter = 62 bp
Exon A = 120 bp
Intron A = 824 bp

Records referencing this document (2)
IDDescription
2record(s) found
Modified Organism1 record
Risk Assessment1 record