Rift Valley Fever Virus glycoproteins Gn and Gc are the major
structural antigens found on the virion particle. Together the two
proteins are present as heterodimers and form the icosahedral shell
of the virion. In vitro Gn and Gc form virus-like
particles and can induce immunity in animals. Baculovirus
expression systems expressing only Gc results in highly
pleiomorphic virus-like particles. Thus, for homogeneous virus
particle surfaces, heterodimer expression (Gn) is required.