CRY14Ab1 is a crystal protein from Bacillus thuringiensis
related to the other crystal proteins CRY1A, CRY3A and CRY4A.
Structurally, the protein contains three domains. The protein has
been demonstrated to have nematicidal activity against
Caenorhabditis elegans, Panagrellus redivivus,
Nippostrongylus brasiliensis, Distolabrellus
veechi, Meloidogyne spp. (root knot nematodes),
Rotylenchulus reniformis (reniform nematode),
Hopiolaimus spp. (Lance nematode), Pratylenchus
spp. and Heterodera glycines (soybean cyst nematode).
The protein is thought to act in the intestine of nematodes. During
feeding assays with C. elegans, the symptoms included
constriction and thinning of intestinal cells, shrinkage of the
gut, vacuolization and a degenerative appearance. Due to its
relation to other crystal proteins, it is thought that CRY14A may
also have insecticidal properties as well.