Canarypox virus (CNPV) is an avipoxvirus and etiologic agent of
canarypox, a disease of birds both in the wild and in commercial
aviaries, where significant losses result.
CNPV has been successfully used as a host range-restricted
mammalian expression vector and is a vaccine vector of increasing
importance, with CNPV-based veterinary vaccines commercially
available and human vaccines undergoing clinical trials. Licensed
and experimental CNPV-based vaccines, most of which utilize the
highly attenuated ALVAC strain of CNPV, encode a range of pathogen
and tumor-associated antigens, including those from rabies virus,
canine distemper virus, feline leukemia virus, human
immunodeficiency virus, human cytomegalovirus, hepatitis B and C
viruses, Plasmodium falciparum, melanoma, and colorectal cancer.
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