E1 and E2 genes are necessary and sufficient for episomal viral DNA
replication in cultured cells and in a cell-free system.
E1 and E2 genes mediate plasmid DNA replication in cultured cells
and in a cell extract.
Regulatory gene function
E1 protein is required for viral DNA replication and can bind to
the origin of replication alone or in a complex with the E2
transactivator protein.
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