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Gene and DNA Sequence
Record information and status
Record ID
Date of creation
2008-07-22 14:34 UTC (mia.crager@cbd.int)
Date of last update
2021-02-12 16:36 UTC (austein.mcloughlin@cbd.int)
Date of publication
2021-02-12 16:36 UTC (austein.mcloughlin@cbd.int)

General information
Name of the gene or DNA sequence
5-enolpyruvylshikimate-3-phosphate synthase
Alternate Genetic Element Name (synonyms)
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
Donor organism
Donor organism
Escherichia coli - ECOLX
Characteristics of the protein coding sequence
Name of the protein expressed by the coding sequence
5-enolpyruvylshikimate-3-phosphate synthase
Biological function
Involved in EPSP biosynthesis. The aroA gene, which encodes 5-enolpyruvylshikimate-3-phosphate synthase , an enzyme of the common aromatic biosynthetic pathway, the enzyme participates in biosynthesis of the aromatic amino acids phenylalanine, tyrosine and tryptophan.

The enzyme is a target for herbicides as these amino acids are only synthesized in plants and microorganisms. Glyphosate acts as a competitive inhibitor for phosphoenolpyruvate, as substrate of EPSPS, and is used as a broad-spectrum systemic herbicide.
Related trait(s) or use(s) in biotechnology

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