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Gene and DNA Sequence
Record information and status
Record ID
Date of creation
2008-08-13 15:16 UTC (manoela.miranda@cbd.int)
Date of last update
2016-06-22 15:43 UTC (dina.abdelhakim@cbd.int)
Date of publication
2016-06-22 15:43 UTC (dina.abdelhakim@cbd.int)

General information
Name of the gene or DNA sequence
Double Mutant 5-enolpyruvylshikimate-3-phosphate synthase
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
Donor organism
Donor organism
Zea mays - Maize, Corn, MAIZE
Characteristics of the protein coding sequence
Name of the protein expressed by the coding sequence
Double mutant 5-EnolPyruvylShikimate-3-Phosphate Synthase
Biological function
Glyphosate tolerance can be conferred by decreasing the herbicide's ability to inhibit the enzyme 5-enolpyruvylshikimate-3-phosphate synthase, which is essential for the biosynthesis of aromatic amino acids in all plants, fungi, and bacteria.

Glyphosate tolerance is based upon the expression of the double mutant 5-enolpyruvylshikimate-3-phosphate synthase (2mEPSPS) protein. The 2mEPSPS protein, with a lower binding affinity for glyphosate, is highly resistant to inhibition by glyphosate and thus allows sufficient enzyme activity for the plants to grow in the presence of herbicides that contain glyphosate.
Related trait(s) or use(s) in biotechnology

Records referencing this document (278)
278record(s) found
Country's Decision or any other Communication126 records
Modified Organism20 records
Organization3 records
Risk Assessment129 records