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Genetic element
(GENE)
published: 11 Dec 2008
last updated: 29 Jun 2012
Killer Protein 4
EN
CS-KP4
EN
Protein coding sequence
No
-
BCH-ORGA-SCBD-47789-6 Organism Ustilago maydis virus H1Viruses
EN
Killer protein 4
EN
KP4 specifically inhibits voltage-gated calcium channels inhibiting cell growth and division by blocking calcium import.
The KP4 gene is derived from the genome of a double-stranded RNA virus (Ustilago Maydis Virus 4, UmV4, Totiviridae, Totivirus, 00.075.0.01), which is present in the tissue of certain fungal strains of corn smut (Ustilago maydis). Expression of the KP4 gene leads to the production of the KP4 (killer protein 4).
In Ustilago maydis cells KP4 leads to a reversible inhibition of hyphal growth, but does not kill off competing strains. It is expected that plants expressing the KP4 protein are less susceptible to damage caused by the phytopathogenic fungi Ustilago spec.
EN
The KP4 gene is derived from the genome of a double-stranded RNA virus (Ustilago Maydis Virus 4, UmV4, Totiviridae, Totivirus, 00.075.0.01), which is present in the tissue of certain fungal strains of corn smut (Ustilago maydis). Expression of the KP4 gene leads to the production of the KP4 (killer protein 4).
In Ustilago maydis cells KP4 leads to a reversible inhibition of hyphal growth, but does not kill off competing strains. It is expected that plants expressing the KP4 protein are less susceptible to damage caused by the phytopathogenic fungi Ustilago spec.
EN
- Structure and heterologous expression of the Ustilago maydis viral toxin KP4 [ English ]
- Ustilago maydis virus P4 killer toxin: Characterization, partial amino terminus sequence, and evidence for glycosylation [ English ]
- Structure and function of a virally encoded fungal toxin from Ustilago maydis a fungal and mammalian Ca2+ channel inhibitor.pdf [ English ]
- KP4 fungal toxin inhibits growth in Ustilago maydis by blocking calcium uptake.pdf [ English ]
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