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Gene and DNA Sequence
Record information and status
Record ID
48073
Status
Published
Date of creation
2009-01-09 13:13 UTC (manoela.miranda@cbd.int)
Date of last update
2016-05-05 17:02 UTC (dina.abdelhakim@cbd.int)
Date of publication
2016-05-05 17:02 UTC (dina.abdelhakim@cbd.int)

General information
Name of the gene or DNA sequence
Acetohydroxy acid synthase gene
Alternate Genetic Element Name (synonyms)
Acetolactate Synthase (ALS) gene
Abbreviation
CS-ahas-ARATH
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
No
Donor organism
Donor organism
Arabidopsis thaliana - Thale cress, Mouse-ear cress, Arabidopsis, ARATH
Characteristics of the protein coding sequence
Name of the protein expressed by the coding sequence
Acetohydroxy acid synthase
Biological function
AHAS is an essential enzyme for many organisms as it catalyzes the first step in the biosynthesis of the branched-chain amino acids valine, isoleucine, and leucine.

A common mutant form of the ahas gene was isolated from a herbicide-resistant Arabidopsis thaliana which differs from the wild type gene by only a single base pair. A "G" to "A" point mutation results in a single amino acid substitution in which the serine residue at position 653 is replaced by asparagine (S653N)

Tests using the mutant isoform of the ahas gene showed that it confers tolerance to sulfonylurea herbicides in plants. The ahas mutant isoform may, therefore, be used as a selectable marker in transgenic plants. 
Related trait(s) or use(s) in biotechnology

Records referencing this document (51)
IDDescription
51record(s) found
Country's Decision or any other Communication17 records
Modified Organism11 records
Risk Assessment23 records