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Information Resource
Record information and status
Record ID
Date of creation
2010-03-09 16:44 UTC (andrew.bowers@cbd.int)
Date of last update
2012-05-10 17:06 UTC (dina.abdelhakim@cbd.int)
Date of publication
2012-05-10 17:06 UTC (dina.abdelhakim@cbd.int)

General Information
Biosafety and risk assessment in the use of genetically modified mosquitoes for disease control
Yeya T. Touré, Ayoade M.J. Oduola, Johannes Sommerfeld and Carlos M. Morel
Organization(s) involved in the publication of this resource
World Health Organization (WHO)
Special Programme for Research and Training in Tropical Diseases (TDR)
20 Avenue Appia
Geneva 27
Switzerland, CH-1211
Url:TDR: For research on diseases of poverty
  • English
Summary, abstract or table of contents
The development and implementation of the release of genetically modified mosquitoes (GMM) for interrupting pathogen transmission represent a major challenge, despite the fact that several achievements have been made about Anopheles and Aedes mosquitoes. There are major biotechnology challenges remaining about the improvement of the stability of a gene construct and its expression for a robust and complete interruption of pathogen transmission and the devise of safe means of spreading foreign antipathogen genes through mosquito populations in the wild. The implementation obstacles to overcome include proper risk assessment and management, conduct of studies to ensure safety for humans and the environment, devise of appropriate control strategies based on sound gene-driving systems, address properly ethical, legal and social implications of the release of GMM and public concerns. Although the development of GMM as disease-control tool is technically feasible, for proper implementation no field release must be undertaken until clear scientific proof of safety for humans and the environment and efficacy is provided and ELSI concerns and public acceptance are properly addressed.
Thematic areas
  • Scientific and technical issues
    • Risk assessment
  • Risk assessment and risk management
Background material to the “Guidance on risk assessment of living modified organisms”
Is this document is recommend as background material for the “Guidance on Risk Assessment of Living Modified Organisms”
Section(s) of the “Guidance on Risk Assessment of Living Modified Organisms” this background material is relevant
  • 5. Risk assessment of living modified mosquitoes species that act as vectors of human and animal diseases
Additional Information
Type of resource
  • Book / Book chapter
Publisher and its location
Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva
6-page PDF file
Keywords and any other relevant information

genetically modified mosquito; biosafety; risk assessment; disease
control; malaria; dengue