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Gene and DNA Sequence
Record information and status
Record ID
Date of creation
2010-07-19 15:21 UTC (german_bch@bvl.bund.de)
Date of last update
2012-07-24 20:50 UTC (dina.abdelhakim@cbd.int)
Date of publication
2012-07-24 20:50 UTC (dina.abdelhakim@cbd.int)

General information
Name of the gene or DNA sequence
Gamma-glutamylcysteine Synthetase I gene
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
Donor organism
Donor organism
Escherichia coli - ECOLX
Characteristics of the protein coding sequence
Name of the protein expressed by the coding sequence
Gamma-glutamylcysteine synthetase (GSH)
Biological function
Gamma-glutamylcysteine synthase plays an important role in the synthesis of glutathione (glutamyl-cysteinyl-glycine, GSH) insofar as it specifically catalyses the ligation of glutamic acid and cysteine to form glutamylcysteine under energy consumption. Other gamma-ECS substrates are not known. Glutathione is formed in a second step, in which glycine is bound to the dipeptide by glutathione synthetase.

Glutathione performs several functions in plant cells. As an antioxidant, it protects plant cells against oxidation, acts as a reserve for organic sulphur and as a precursor for phytochelatins [(gamma-glutamylcysteine)n-glycine; n=2-11] it contributes to the detoxification of xenobiotics and heavy metals. This is brought about by the formation of stable complexes with metal ions from the thiol group of the cysteine residues of phytochelatins, which are pumped under ATP consumption into the plant cell vacuoles where they are stored.
Related trait(s) or use(s) in biotechnology
Additional Information
Additional Information
An increased production of glutathione is considered essential if the plant to perform its intended function, i.e. the improved uptake of heavy metals. The formation of phytochelatins necessary for this may alter the source-sink distribution of the individual components (in particular cysteine and glutamic acid).

Records referencing this document (3)
3record(s) found
Country's Decision or any other Communication1 record
Modified Organism1 record
Risk Assessment1 record