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Record information and status
Record ID
Date of creation
2012-05-11 19:26 UTC (dina.abdelhakim@cbd.int)
Date of publication
2012-05-11 19:26 UTC (dina.abdelhakim@cbd.int)

General Information
Female-specific flightless phenotype for mosquito control
Guoliang Fu, Rosemary S. Lees, Derric Nimmo, Diane Aw, Li Jin, Pam Gray, Thomas U. Berendonk, Helen White-Cooper, Sarah Scaife, Hoang Kim Phuc, Osvaldo Marinotti, Nijole Jasinskiene, Anthony A. James , and Luke Alphey
Author’s contact information
Luke Alphey
E-mail: aajames@uci.edu or luke.alphey@oxitec.com.
  • English
Publication date
Summary, abstract or table of contents

Dengue and dengue hemorrhagic fever are increasing public health problems with an estimated 50-100 million new infections each year. Aedes aegypti is the major vector of dengue viruses in its range and control of this mosquito would reduce significantly human morbidity and mortality. Present mosquito control methods are not sufficiently effective and new approaches are needed urgently. A "sterile-male-release" strategy based on the release of mosquitoes carrying a conditional dominant lethal gene is an attractive new control methodology. Transgenic strains of Aedes aegypti were engineered to have a repressible female-specific flightless phenotype using either two separate transgenes or a single transgene, based on the use of a female-specific indirect flight muscle promoter from the Aedes aegypti Actin-4 gene. These strains eliminate the need for sterilization by irradiation, permit male-only release ("genetic sexing"), and enable the release of eggs instead of adults. Furthermore, these strains are expected to facilitate area-wide control or elimination of dengue if adopted as part of an integrated pest management strategy.
Thematic areas
  • Scientific and technical issues
    • Risk assessment
Background material to the “Guidance on risk assessment of living modified organisms”
Is this document is recommend as background material for the “Guidance on Risk Assessment of Living Modified Organisms”
Section(s) of the “Guidance on Risk Assessment of Living Modified Organisms” this background material is relevant
  • 5. Risk assessment of living modified mosquitoes species that act as vectors of human and animal diseases
Additional Information
Type of resource
  • Article (journal / magazine / newspaper)
doi: 10.1073/pnas.1000251107
Publisher and its location
National Academy of Sciences of the United States of America
New York
Open Access
9 page PDF
Proceedings of the national Academy of Sciences (PNAS)
Keywords and any other relevant information
Keywords: Aedes aegypti, dengue virus, sterile insect technique, genetic control, population suppression