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Record information and status
Record ID
Date of creation
2012-05-14 19:00 UTC (dina.abdelhakim@cbd.int)
Date of publication
2012-05-14 19:00 UTC (dina.abdelhakim@cbd.int)

General Information
Mosquito transgenesis: what is the fitness cost?
Mauro T. Marrellia, Cristina K. Moreiraa, David Kellyb, Luke Alpheyb, Marcelo Jacobs-Lorena
Author’s contact information
Jacobs-Lorena, M.

Johns Hopkins University, Bloomberg School of Public Health Department of Molecular Microbiology and Immunology and Malaria Research Institute,
615 North Wolfe St, Baltimore, MD 21205, USA

Email: mlorena@jhsph.edu
  • English
Publication date
Summary, abstract or table of contents

The generation of transgenic mosquitoes with a minimal fitness load is a prerequisite for the success of strategies for controlling mosquito-borne diseases using transgenic insects. It is important to assemble as much information as possible on this subject because realistic estimates of transgene fitness costs are essential for modeling and planning release strategies. Transgenic mosquitoes must have minimal fitness costs, because such costs would reduce the effectiveness of the genetic drive mechanisms that are used to introduce the transgenes into field mosquito populations. Several factors affect fitness of transgenic mosquitoes, including the potential negative effect of transgene products and insertional mutagenesis. Studies to assess fitness of transgenic mosquitoes in the field (as opposed to the laboratory) are still needed.
Thematic areas
  • Scientific and technical issues
    • Risk assessment
Background material to the “Guidance on risk assessment of living modified organisms”
Is this document is recommend as background material for the “Guidance on Risk Assessment of Living Modified Organisms”
Section(s) of the “Guidance on Risk Assessment of Living Modified Organisms” this background material is relevant
  • 5. Risk assessment of living modified mosquitoes species that act as vectors of human and animal diseases
Additional Information
Type of resource
  • Article (journal / magazine / newspaper)
Publisher and its location
© 2006 Elsevier Ltd.
6 page PDF
TRENDS in Parasitology
Keywords and any other relevant information
Citation: TRENDS in Parasitology Vol.22 No.5 May 2006