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Record information and status
Record ID
Date of creation
2012-05-14 19:07 UTC (dina.abdelhakim@cbd.int)
Date of publication
2012-05-14 19:07 UTC (dina.abdelhakim@cbd.int)

General Information
Transgenic malaria-resistant mosquitoes have a fitness advantage when feeding on Plasmodium-infected blood
Mauro T. Marrelli, Chaoyang Li, Jason L. Rasgon, and Marcelo Jacobs-Lorena
Author’s contact information
Marcelo Jacobs-Lorena
E-mail: mlorena@jhsph.edu.
  • English
Publication date
Summary, abstract or table of contents

The introduction of genes that impair Plasmodium development into mosquito populations is a strategy being considered for malaria control. The effect of the transgene on mosquito fitness is a crucial parameter influencing the success of this approach. We have previously shown that anopheline mosquitoes expressing the SM1 peptide in the midgut lumen are impaired for transmission of Plasmodium berghei. Moreover, the transgenic mosquitoes had no noticeable fitness load compared with nontransgenic mosquitoes when fed on noninfected mice. Here we show that when fed on mice infected with P. berghei, these transgenic mosquitoes are more fit (higher fecundity and lower mortality) than sibling nontransgenic mosquitoes. In cage experiments, transgenic mosquitoes gradually replaced nontransgenics when mosquitoes were maintained on mice infected with gametocyte-producing parasites (strain ANKA 2.34) but not when maintained on mice infected with gametocyte-deficient parasites (strain ANKA 2.33). These findings suggest that when feeding on Plasmodium-infected blood, transgenic malaria-resistant mosquitoes have a selective advantage over nontransgenic mosquitoes. This fitness advantage has important implications for devising malaria control strategies by means of genetic modification of mosquitoes.
Thematic areas
  • Scientific and technical issues
    • Risk assessment
Background material to the “Guidance on risk assessment of living modified organisms”
Is this document is recommend as background material for the “Guidance on Risk Assessment of Living Modified Organisms”
Section(s) of the “Guidance on Risk Assessment of Living Modified Organisms” this background material is relevant
  • 5. Risk assessment of living modified mosquitoes species that act as vectors of human and animal diseases
Additional Information
Type of resource
  • Article (journal / magazine / newspaper)
doi: 10.1073/pnas.0609809104
Publisher and its location
National Academy of Sciences of the United States of America
New York
© 2007 by The National Academy of Sciences of the USA
4 page PDF
Proceedings of the National Academy of Science (PNAS)
Keywords and any other relevant information
Keywords: malaria control, genetic modification, gene drive

Citation: PNAS March 27, 2007 vol. 104 no. 13 5580-5583