Sorghum with modified levels of vitamin A, zinc and iron | BCH-LMO-SCBD-103628 | Living Modified Organism | Biosafety Clearing-House


Living Modified Organism (LMO)

Decisions on the LMO Risk Assessments  
published: 18 Jun 2012 last updated: 24 Aug 2012
Living Modified Organism identity
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Sorghum with modified levels of vitamin A, zinc and iron
  • - Organization: Pioneer Hi-Bred International, Inc. () | BCH-CON-SCBD-49391-1
    Pioneer Hi-Bred International, Inc. ()
    PO Box 1000 Johnston IA 50131-0184 USA
    Phone: +1-515-270-3200,
    Fax: +1-515-334-4415,
Sorghum ABS188 was genetically modified through a transformation mediated by Agrobacterium to improve bioavailable levels of vitamin A, zinc and iron.

Gene LPA1 was inserted to reduce the synthesis of phytic acid which reduces sorghum’s zinc and iron availability to human. Genes PSY1 and CRT1 were inserted in sorghum to synthesize phytoene synthetases and phytoene desaturase which are required for the synthesis of beta-carotene (vitamin A).
The term “Recipient organism” refers to an organism (either already modified or non-modified) that was subjected to genetic modification, whereas “Parental organisms” refers to those that were involved in cross breeding or cell fusion.
Characteristics of the modification process
  • Agrobacterium-mediated DNA transfer
Some of these genetic elements may be present as fragments or truncated forms. Please see notes below, where applicable.
Globulin 1 Promoter: Obtained from Zea mays strain PHP20926. The promoter sequence contains a base pair change and a base par addition at the 3' end to correct the ORF as follows: TATAAATGCGCG changed to TATAAATCCCGCG

Globulin 1 Terminator: Obtained from Zea mays strain PHP20926. The terminator sequence contains 2 base pair changes at the 5' end to expose an ORF. The sequence is as follows: GCTCGCCAAAA changed to GCTCGCTCAAA.
LMO characteristics
  • Food
  • Feed
Detection method(s)
Additional Information
Records referencing this document Show in search
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Country's Decision or any other Communication Living modified organism(s) 2
Risk Assessment generated by a regulatory process Living modified organism(s) 2