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Dr Alexis Henry Gaetan Goux
President of CIBio
Ceva Saúde Animal Ltda (CEVA)
Rua Manuel Joaquim Filho, 303 Pulínia - SP
Paulínia, São Paulo
VECTORMUNE® IBD is a chicken vaccine that contains a
genetically engineered Marek's Disease virus of serotype 3 (turkey
Herpesvirus or HVT) expressing Infectious Bursal Disease key
protective antigens, therefore providing immunity against IBD.
The term Recipient organism refers to an organism (either already modified or non-modified) that was subjected to genetic modification, whereas Parental organisms refers to those that were involved in cross breeding or cell fusion.
Meleagrid alphaherpesvirus 1 - Turkey herpesvirus, Meleagrid herpesvirus 1
Some of these genetic elements may be present as fragments or truncated forms. Please see notes below, where applicable.
Beta-actin gene promoter - Gallus gallus - Chicken, CHICK
Viral Protein 2 gene - Infectious bursal disease virus - Gumboro virus
Production of medical or pharmaceutical compounds (human or animal) - Vaccines
A 2.9 kb region of the HVT genome was inserted into the pUC18
vector. This fragment contained the incomplete open reading frame
(ORF) of UL44 and the complete ORFs of UL45 and UL46 from the HVT
The chicken beta-actin promoter and transcription termination
sequences from SV40 and UL46 were inserted into the HVT genoming
The VP2 gene from the Delaware Variant of the IBDV was amplified
from viral RNA using RT-PCR and inserted in to the pUC18 vector in
between the beta-actin promoter and termination sequences from SV40
This construct and the the parental HVT strain were co-transformed
into chicken embryo fibroblasts and incubated under conditions that
favour homologous recombination.
Viral particles were cultivated from the chicken embryo fibroblasts
and plaques were expanded and screened and selected for the
expression of the VP2 gene.
- Production of medical or pharmaceutical compounds (human or animal)