Date of creation
2014-11-03 01:01 UTC (email@example.com)
Date of publication
2014-11-03 03:31 UTC (firstname.lastname@example.org)
Decision for the Safety Assessment of Syngenta's corn Bt11 x MIR162
x MIR604 x GA21 for Direct Use as food and feed or for processing
Department of Agriculture
Elliptical Road, Diliman
SYN-BTØ11-1 x SYN-IR162-4 x SYN-IR6Ø4-5 x MON-ØØØ21-9 - Agrisure Viptera® 4 Maize
Resistance to diseases and pests - Insects - Coleoptera (beetles) - Western corn rootworm (Diabrotica virgifera), Lepidoptera (butterflies and moths)
Resistance to herbicides - Glufosinate, Glyphosate
Selectable marker genes and reporter genes Show detection method(s)
- LMOs for direct use as feed
- LMOs for direct use as food
- LMOs for processing
The six proteins (Cry1Ab, PAT,Vip3Aa20, mCry3A, PMI and
EPSPS) show no homology to any known mammalian allergen or
Based on the modes of action of the Cry1Ab, PAT, Vip3Aa20, mCry3A,
PMI and EPSPS proteins, and
the location of these proteins' accumulation in the plant cells,
there is no known mechanism of interaction among the gene products
that could lead to adverse effects in human and animals.
There is no evidence suggesting that the six proteins will interact
to form some new allergen or toxin since each has distinct mode of
action and are not likely to interact.
After reviewing the scientific data and information relevant to the
combined trait product corn Bt11 x
MIR162 x MIR604 x GA21 application of Syngenta Philippines, Inc.,it
is concluded that no interaction found between/among the combined
traits. Hence, this plant product was found to be as safe as its
entional corn and can substitute for its traditional counterpart
for direct use as food, feed and for processing and is therefore
approved for direct use as food, or feed or for processing.
A biosafety notification for combined trait product : corn Bt11 x
MIR162 x MIR604 x GA21 and all progenies derived from crosses of
the product with any conventionally bred corn and corn
approved - biotech events for direct use as food, feed or for
processing was issued to Syngenta Philippines Inc.
BT11 X MIR162 X MIR604 X GA21 is found to be as safe as its
conventional counterpart and does not pose any significant risk to
human and animal health.
This LMO will be directly used for food, feed and processing.
Quantitative diagnostic lateral flow strips, ELISA and PCR for
routine quantitative and semi-quantitative detection of
transgenes. For higher sensitivity, real-time PCR.Methods and
protocols for safe handling, storage, transport and use are all
indicated in the implementing rules and regulations (IRRs), memo
circulars supplementing Administrative Order No. 8 of the
Department of Agriculture; also the general guidelines of the
National Committee on Biosafety of the Philippines.
The combined trait product BT11 X MIR162 X MIR604 X GA21 is
intended for direct use as food, feed and for processing.
All relevant references submitted by the technology developer in
their application; other references requested by the Scientific and
Technical Review Panel (STRP) members and DA Regulatory Agencies
during the evaluation of BT11 X MIR162 X MIR604 XGA21.
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