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Gene and DNA Sequence
Record information and status
Record ID
Date of creation
2015-07-30 02:16 UTC (anita@nre.gov.my)
Date of publication
2015-07-30 17:59 UTC (dina.abdelhakim@cbd.int)

General information
Name of the gene or DNA sequence
Protamine 1 coding sequence
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
Donor organism
Donor organism
Homo sapiens - HUMAN
Characteristics of the protein coding sequence
Name of the protein expressed by the coding sequence
Human Protamine 1
Biological function
Protamines are polycationic, highly basic polypeptides that bind to DNA and substitute for the somatic histones and transition proteins required for spermatogenesis in vertebrates.

The highly positively charged nature of protamines allows them to electrostatically bind to the negatively charged heparin molecules there fore neutralizing the anticoagulant effects of heparin following cardiovascular surgery.
Related trait(s) or use(s) in biotechnology
  • Production of medical or pharmaceutical compounds (human or animal)
Additional Information
Other relevant website address or attached documents

Records referencing this document (3)
3record(s) found
Country's Decision or any other Communication1 record
Modified Organism1 record
Risk Assessment1 record