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Gene and DNA Sequence
Record information and status
Record ID
Date of creation
2016-08-01 17:10 UTC (dina.abdelhakim@cbd.int)
Date of publication
2016-08-01 17:10 UTC (dina.abdelhakim@cbd.int)

General information
Name of the gene or DNA sequence
Erns coding sequence
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
Donor organism
Donor organism
Pestivirus A - BVDV-1
Characteristics of the protein coding sequence
Name of the protein expressed by the coding sequence
Biological function
Erns is a glycoprotein found on the surface of the BVDV viron. In addition to being a virion protein, a proportion of Erns is secreted from infected cells into the extracellular environment as a consequence of it lacking a typical transmembrane anchor domain.

The biological significance of secreted Erns has not been determined. However, Erns has two defined activities. First, Erns has an RNase activity that shows a strong preference for single-stranded RNA (ssRNA). Second, Erns glycoproteins of both BVDV and a closely related pestivirus, classical swine fever virus (CSFV), have been shown to bind to cell surface glycosylaminoglycans through residues located close to their C termini.
Related trait(s) or use(s) in biotechnology

Records referencing this document (3)
3record(s) found
Country's Decision or any other Communication1 record
Modified Organism1 record
Risk Assessment1 record