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Gene and DNA Sequence
Record information and status
Record ID
Date of creation
2016-10-25 09:46 UTC (german_bch@bvl.bund.de)
Date of publication
2016-10-31 16:59 UTC (dina.abdelhakim@cbd.int)

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General information
Name of the gene or DNA sequence
2-deoxyglucose-6-phosphate phosphatase gene
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
Donor organism
Donor organism
Saccharomyces cerevisiae - Yeast, YEASX
Characteristics of the protein coding sequence
Name of the protein expressed by the coding sequence
2-desoxyglucose-6-phosphate phosphatase
Biological function
In plant cells a glucose analog, 2-deoxyglucose (2-DOG), is phosphorylated by hexokinase to form 2-DOG-6-phosphate, which competes with glucose-6-phosphate causing cell death through the inhibition of glycolysis, protein synthesis, cell wall polysaccharide synthesis and also protein glycosylation.

DOGR1 gene, which has been isolated from Saccharomyces cerevisiae strain S288C, encodes 2-deoxyglucose-6-phosphate. The enzyme has the ability to convert toxic 2-DOG-6-phosphate to non-toxic products through dephosphorylation.

Therefore, transformed plant cells which carry the DOGR1 gene can be selected on medium containing 2-DOG.
Related trait(s) or use(s) in biotechnology
  • Selectable marker genes and reporter genes

Records referencing this document (3)
3record(s) found
Country's Decision or any other Communication1 record
Modified Organism1 record
Risk Assessment1 record