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Gene and DNA Sequence
Record information and status
Record ID
Date of creation
2017-04-03 12:32 UTC (german_bch@bvl.bund.de)
Date of last update
2017-05-16 20:31 UTC (dina.abdelhakim@cbd.int)
Date of publication
2017-05-16 20:31 UTC (dina.abdelhakim@cbd.int)

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General information
Name of the gene or DNA sequence
Tyrosine suppressor tRNA gene
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
Donor organism
Donor organism
Escherichia coli - ECOLX
Characteristics of the protein coding sequence
Name of the protein expressed by the coding sequence
SupF tyrosine suppressor tRNA gene
Biological function
A suppressor tRNA contains a mutation in the anticodon region that leads to its recognition and binding to a stop codon. This leads to the suppression of protein truncation resulting from a nonsense mutation. Therefore the suppressor tRNA will bind and incorporate its amino acid, instead of the regular release factor binding and causing termination, allowing translation to continue.

The Escherichia coli tyrosine suppressor tRNA incorporates tyrosine at the chain termination codon UAG, thereby suppressing this stop-codon. It has been utilized in several shuttle-vector plasmids.

Records referencing this document (3)
3record(s) found
Country's Decision or any other Communication1 record
Modified Organism1 record
Risk Assessment1 record