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Gene and DNA Sequence
Record information and status
Record ID
Date of creation
2019-05-21 16:57 UTC (austein.mcloughlin@cbd.int)
Date of last update
2019-05-21 19:41 UTC (austein.mcloughlin@cbd.int)
Date of publication
2019-05-21 19:41 UTC (austein.mcloughlin@cbd.int)

General information
Name of the gene or DNA sequence
Nonstructural protein 3
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
Donor organism
Donor organism
Yellow fever virus - YFV 17D
Donor organism point of collection
Yellow fever virus strain 17D
Characteristics of the protein coding sequence
Biological function
Nonstructural protein 3 (NS3) has three enzymatic functions: serine protease, NTPase, and RNA helicase. NS3, along with cofactor nonstructural protein 2B, catalyzes its own autocleavage and cleaves the viral polyprotein. NS3 also functions in viral genome replication as an RNA helicase, unwinding dsRNA in the 3' to 5' direction. Likely, NS3 is involved in viral assembly, potentially interacting with other nonstructural proteins, such as nonstructural protein 2A.

Records referencing this document (3)
3record(s) found
Country's Decision or any other Communication1 record
Modified Organism1 record
Risk Assessment1 record