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Gene and DNA Sequence
Record information and status
Record ID
115356
Status
Published
Date of creation
2020-01-09 21:22 UTC (austein.mcloughlin@cbd.int)
Date of publication
2020-01-09 21:22 UTC (austein.mcloughlin@cbd.int)

General information
Name of the gene or DNA sequence
bleomycin binding protein
Alternate Genetic Element Name (synonyms)
bleomycin resistance protein
Abbreviation
ble
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
No
Donor organism
Donor organism
Escherichia coli - ECOLX
Donor organism point of collection
The resistance protein is encoded on the TN5 transposon.
Characteristics of the protein coding sequence
Biological function
The protein has a high-binding affinity for bleomycin, thus has the ability to sequester bleomycin and confer resistance.
Related trait(s) or use(s) in biotechnology
  • Resistance to antibiotics
  • Resistance to bleomycin
Additional Information
Additional Information
Bleomycin is a glycopeptide antibiotic prodcued by Streptomyces verticillus. Bleomycin is thought to complex with iron (ii) and/or iron (III) to induce the formation of reactive oxygen species, which causes DNA cleavage and inhibit DNA synthesis. Due to its toxicity, the compound is not used in medical treatment as an antibiotic. However, it is used in the clinical treatment of cancerous tumours.

Records referencing this document (1)
IDDescription
1record(s) found
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